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Leukaemia

ल्युकेमिया (रक्ताचा कर्करोग) · ल्यूकेमिया

ल्युकेमिया (रक्ताचा कर्करोग): ल्युकेमिया हा पांढऱ्या रक्तपेशींचा कर्करोग आहे. मुलांमधील ALL ८० टक्क्यांहून अधिक बरा होतो आणि CML गोळ्यांनी अनेक वर्षे नियंत्रणात राहतो.

Leukaemia is a cancer of white blood cells, starting in the bone marrow.

  • Acute lymphoblastic leukaemia (ALL) – the commonest childhood cancer; more than 80% of children are cured with treatment
  • Acute myeloid leukaemia (AML) – mostly adults; needs urgent intensive treatment
  • Acute promyelocytic leukaemia (APL) – a medical emergency, but highly curable with ATRA and arsenic trioxide
  • Chronic myeloid leukaemia (CML) – controlled for many years with daily tablets (imatinib and others)
  • Chronic lymphocytic leukaemia (CLL) – older adults; many need only monitoring, others targeted tablets

Warning signs

Fever and infections, weakness and paleness, bleeding or bruising, bone pain in children, enlarged glands, liver or spleen, very high or very low white cell counts.

Diagnosis

Blood count and smear, bone marrow aspiration and biopsy, flow cytometry, cytogenetics and molecular testing (BCR-ABL, FLT3, NPM1 and others).

Treatment

Chemotherapy protocols, targeted tablets, intrathecal chemotherapy, transfusion support, close monitoring of response (MRD), and transplant consultation for high-risk disease.